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Physiological and hormonal responses to novelty exposure in rats are mainly related to ongoing behavioral activity

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The IARC Working Group concluded that the carcinogenic effects of estrogens and progestogens were inextricably linked to the hormonal milieu and to dose-effect relationships (IARC, 1979, 1987) The role of hormones, including progesterone, in mammary neoplasia in rodents and their relevance to human risk assessment have been reviewed (Russo & Russo, 1996), and it was noted that rodent models mimic some but not all of the complex external and endogenous factors involved in initiation, promotion, and progression of carcinogenesis